Combinatorial Chemistry Review

Alcohol Linkers

A hydroxyl linker based on the tetrahydropyranyl (THP) protecting group has been developed by Thompson and Ellmann. All type of alcohols readily add to dihydropyran and the resulting THP protecting group is stable to strong base, but easily cleaved with acid. This linker is attached to a Merrifield resin.

The generation and cleavage of the THP linker for alcohol

The trityl group is a good acid-labile protecting group for a lot of heteroatoms. The trityl group has been used to anchor alcohols in the synthesis of a library of β-mercaptoketones.

The use of trityl resin in the preparation of β-mercaptoketones