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Introduction

• Principle of Combichem
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• Application of Combichem
• Future of Combichem

Solid Phase Synthesis

• Introduction
• Application

Resins for Solid Phase

• Cross – Linked Polystyrene
• Polyamide Resins
• TentaGel Resins

Linkers for Solid Phase

• Carboxylic Acid Linkers
• Carboxamide Linkers
• Alcohol Linkers
• Amine Linkers
• Traceless Linkers

Solution Phase Synthesis

• Introduction
• Parallel Solution Synthesis
• Example of Application

Analytical Techniques

• Introduction
• DNA – Based Encoding
• Peptide Tag
• Mass Encoding
• Hard Tag
• Radio-Frequency Encoding

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Info for Organic Chemists

Stereoselective Synthesis of Substituted 5,6-Dihydro-2(1H)-pyridinones in Polyphosphate Media

Charles M. Marson, Ursula Grabowska and Asad Fallah, J. Org. Chem. 1994, 59, 291-296

δ-Lactams have been synthesized with excellent stereocontrol of substituents by condensing 3-alkenamides with aryl aldehydes in polyphoshpohoric ester. The scope of the condensation of 3-alkenamides with aryl aldehydes in several phosphate media is examined, and a rationale is proposed regarding γ-lactam versus δ-lactam formation.

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