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Introduction

• Principle of Combichem
• Combinatorial Libraries
• Application of Combichem
• Future of Combichem

Solid Phase Synthesis

• Introduction
• Application

Resins for Solid Phase

• Cross – Linked Polystyrene
• Polyamide Resins
• TentaGel Resins

Linkers for Solid Phase

• Carboxylic Acid Linkers
• Carboxamide Linkers
• Alcohol Linkers
• Amine Linkers
• Traceless Linkers

Solution Phase Synthesis

• Introduction
• Parallel Solution Synthesis
• Example of Application

Analytical Techniques

• Introduction
• DNA – Based Encoding
• Peptide Tag
• Mass Encoding
• Hard Tag
• Radio-Frequency Encoding

Combichem Glossary

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Info for Organic Chemists

Stereocontrolled Synthesis of Cis-2,5-Disubstituted Tetrahydrofurans

Scott D. Rychnovsky and Paul A. Bartlett; J. Am. Chem. Soc. 1981, 103, 3963-3964

The synthesis of polyether antibiotics is currently receiving considerable attention. A particularly challenging aspect of this work is the stereocontrolled construction of the substituted tetrahydrofuran units found in many of these natural products, particularly those units in which there is a cis relationship between substituents at the 2 and 5 positions.

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