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Introduction

• Principle of Combichem
• Combinatorial Libraries
• Application of Combichem
• Future of Combichem

Solid Phase Synthesis

• Introduction
• Application

Resins for Solid Phase

• Cross – Linked Polystyrene
• Polyamide Resins
• TentaGel Resins

Linkers for Solid Phase

• Carboxylic Acid Linkers
• Carboxamide Linkers
• Alcohol Linkers
• Amine Linkers
• Traceless Linkers

Solution Phase Synthesis

• Introduction
• Parallel Solution Synthesis
• Example of Application

Analytical Techniques

• Introduction
• DNA – Based Encoding
• Peptide Tag
• Mass Encoding
• Hard Tag
• Radio-Frequency Encoding

Combichem Glossary

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Info for Organic Chemists

α-Amino carbanions. A second generation formamidine for facile deprotonation leading to α-quaternary substitution

Michael A. Gonzaiez and A.I.Meyers, Tetrahedron Letters, Vol. 30, No 1, pp. 47-50, 1989

Formamidines derived from o-methoxymethylaniline (MMA) allow proton removal of tertiary protons in 1-substituted-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolines.

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