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Introduction

• Principle of Combichem
• Combinatorial Libraries
• Application of Combichem
• Future of Combichem

Solid Phase Synthesis

• Introduction
• Application

Resins for Solid Phase

• Cross – Linked Polystyrene
• Polyamide Resins
• TentaGel Resins

Linkers for Solid Phase

• Carboxylic Acid Linkers
• Carboxamide Linkers
• Alcohol Linkers
• Amine Linkers
• Traceless Linkers

Solution Phase Synthesis

• Introduction
• Parallel Solution Synthesis
• Example of Application

Analytical Techniques

• Introduction
• DNA – Based Encoding
• Peptide Tag
• Mass Encoding
• Hard Tag
• Radio-Frequency Encoding

Combichem Glossary

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Info for Organic Chemists

(S)-3-Aminothiolane: A New Chiral Building Block

E.V.Dehmlow, R.Westerheide; Synthesis 1992, p. 947-949

The racemate of the title compound and the respective sulfone have been used extensively as building blocks for diverse pharmacological agents, such as antitumor compounds, antiradiation compounds, sweeteners, gastric antisecratory and antifertility agents, analogues of antibiotics, fungicides, and others. We report here on a simple synthesis of the title compound which was discovered incidentally in the course of another project.

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