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Introduction

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• Future of Combichem

Solid Phase Synthesis

• Introduction
• Application

Resins for Solid Phase

• Cross – Linked Polystyrene
• Polyamide Resins
• TentaGel Resins

Linkers for Solid Phase

• Carboxylic Acid Linkers
• Carboxamide Linkers
• Alcohol Linkers
• Amine Linkers
• Traceless Linkers

Solution Phase Synthesis

• Introduction
• Parallel Solution Synthesis
• Example of Application

Analytical Techniques

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• DNA – Based Encoding
• Peptide Tag
• Mass Encoding
• Hard Tag
• Radio-Frequency Encoding

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Info for Organic Chemists

New Synthesis of Substituted Quinoline N-Oxides via Cyclization of Alkylidene O-Nitroarylacetonitriles

Zbigniew Wrobel, Andrej Kwast, Mieczyslaw Makosza, Synthesis 1993, p. 31-32

Substituted quinoline N-oxides are prepared via base induced cyclization of alkylidene derivates of o-nitroarylacetonitriles which are readily available via the vicarious nucleophilic substitution cyanomethylation of nitroarenes followed by Knoevenagel condensation.

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